:root{--ink:#101010;--orange:#ff9418;--muted:#626262;--paper:#f4f4f4;--line:#dedede;--font:'DM Sans',Arial,sans-serif}*{box-sizing:border-box}html{scroll-behavior:smooth;scroll-padding-top:34px}body{margin:0;background:#fff;color:var(--ink);font-family:var(--font);font-size:18px;line-height:1.7}button,input{font:inherit}button,a{-webkit-tap-highlight-color:transparent}button{cursor:pointer}a{color:inherit;text-underline-offset:4px}img{max-width:100%;display:block}button:focus-visible,a:focus-visible,summary:focus-visible,input:focus-visible,[tabindex]:focus-visible{outline:3px solid #c65b00;outline-offset:5px}h1,h2,h3,p{margin:0}h1,h2,h3{font-family:Manrope,Arial,sans-serif;line-height:1.12;letter-spacing:-.045em}h2{font-size:clamp(36px,3.6vw,55px);font-weight:750}h3{font-weight:750}p+p{margin-top:23px}em{font-style:normal;color:#c45a00}.shell{width:min(1320px,calc(100% - 96px));margin:auto}.skip{position:fixed;top:-100px;left:16px;z-index:100;background:#fff;padding:12px 18px}.skip:focus{top:10px}.read-progress{position:fixed;height:3px;background:var(--orange);top:0;left:0;width:0;z-index:100}.site-header{height:91px;padding:0 48px;display:flex;align-items:center;justify-content:space-between;background:#080808;color:#fff;border-bottom:1px solid #ffffff18}.brand{display:flex;align-items:center;gap:22px;text-decoration:none}.brand img{width:158px;height:auto}.brand-domain{border-left:1px solid #454545;padding-left:21px;font-size:22px;font-weight:800;letter-spacing:-.06em}.brand-domain span{color:var(--orange)}.site-header nav{display:flex;align-items:center;gap:32px}.site-header nav>a:not(.button){font-size:14px;text-decoration:none;color:#d3d3d3}.site-header nav>a:not(.button):hover{color:var(--orange)}.button{border:0;border-radius:5px;display:inline-flex;align-items:center;justify-content:center;gap:30px;background:var(--orange);color:#101010;text-decoration:none;font-weight:750;font-size:16px;line-height:1.35;padding:19px 25px;transition:background .15s,transform .15s}.button:hover{background:#ffad4b;transform:translateY(-2px)}.button span{font-size:23px;font-weight:400}.button.small{font-size:14px;padding:13px 18px;gap:20px}.hero{position:relative;isolation:isolate;background:#080808;color:white;min-height:800px;overflow:hidden}.hero-art{position:absolute;inset:0;z-index:-3;width:100%;height:100%;object-fit:cover;object-position:60% center}.hero-shade{position:absolute;inset:0;z-index:-2;background:linear-gradient(90deg,rgba(7,7,7,.98) 0%,rgba(7,7,7,.92) 26%,rgba(7,7,7,.30) 53%,rgba(7,7,7,0) 77%),linear-gradient(0deg,rgba(7,7,7,.9) 0%,transparent 35%)}.hero-inner{padding-top:65px;padding-bottom:46px}.edition{display:flex;align-items:center;gap:12px;color:#c4c4c4;font-size:10px;letter-spacing:.15em;font-weight:600}.edition-line{height:1px;width:28px;background:var(--orange)}.edition-separator{color:#777;margin:0 1px}.hero h1{font-size:clamp(66px,6.5vw,100px);line-height:1.01;letter-spacing:-.065em;margin-top:29px;max-width:630px;font-weight:750}.hero h1 span{color:var(--orange)}.hero-deck{font-size:24px;line-height:1.38;letter-spacing:-.02em;margin-top:26px;max-width:540px}.hero-copy{max-width:440px;font-size:15px;line-height:1.7;color:#bdbdbd;margin-top:18px}.hero-actions{display:flex;align-items:center;gap:23px;margin-top:31px}.hero-actions .button{padding:15px 20px;font-size:14px}.quiet-link{font-size:13px;text-decoration:none;border-bottom:1px solid #777;padding-bottom:4px}.hero-meta{display:flex;gap:18px;margin-top:42px;font-size:11px;color:#b9b9b9;flex-wrap:wrap}.hero-meta span+span{border-left:1px solid #5b5b5b;padding-left:18px}.hero-caption{position:absolute;right:6%;bottom:56px;text-align:right;border-top:1px solid #ffffff40;padding-top:16px;width:285px}.hero-caption span{font-size:9px;letter-spacing:.17em;color:#bbb}.hero-caption p{font-size:20px;font-family:Manrope;line-height:1.35;margin-top:9px;letter-spacing:-.03em}.guide-strip{display:grid;grid-template-columns:repeat(3,1fr);background:#f4f4f4;border-bottom:1px solid var(--line);padding:25px max(48px,calc((100% - 1320px)/2));gap:35px}.guide-strip>div{display:flex;align-items:flex-start;gap:17px}.guide-strip>div>span{font-size:11px;color:#b95000;padding-top:5px}.guide-strip strong{display:block;font-size:15px;line-height:1.5}.guide-strip small{display:block;font-size:12px;color:#626262}.eyebrow{font-family:var(--font);font-size:10px;font-weight:750;letter-spacing:.16em;line-height:1.6;color:#a54b00}.opening{display:grid;grid-template-columns:1fr 1.2fr;gap:12%;padding-top:112px;padding-bottom:100px}.opening h2{margin-top:20px;font-size:clamp(40px,3.7vw,58px);line-height:1.16}.side-caption{color:#777;font-size:13px;line-height:1.6;max-width:270px;margin-top:26px}.opening .lead{font-size:23px;line-height:1.5;letter-spacing:-.025em;font-weight:500}.opening-copy>p:not(.lead){font-size:17px;color:#505050}.quick-answer{border-top:2px solid var(--orange);margin:32px 0 24px;padding-top:19px}.quick-answer p{font-size:15px;line-height:1.7;margin-top:10px}.text-link{font-size:14px;font-weight:700;text-decoration:none;border-bottom:1px solid #b1b1b1;padding-bottom:5px;display:inline-block}.text-link span{margin-left:15px}.section-top{display:flex;justify-content:space-between;gap:50px;align-items:flex-end;margin-bottom:30px}.section-top h2{margin-top:13px;font-size:43px}.section-top>p{width:310px;font-size:15px;color:#626262}.model-section{padding-bottom:113px}.model-tabs{display:grid;grid-template-columns:repeat(3,1fr);border:1px solid #d8d8d8;border-bottom:0}.model-tabs button{border:0;border-right:1px solid #d8d8d8;background:#f5f5f5;padding:21px 20px;text-align:left;font-size:14px;font-weight:700;line-height:1.4}.model-tabs button:last-child{border-right:0}.model-tabs button span{font-size:10px;display:block;margin-bottom:6px;color:#626262}.model-tabs button[aria-selected=true]{background:var(--orange)}.model-tabs button[aria-selected=true] span{color:#603000}.model-panel{background:#141414;color:#fff;padding:49px 46px;display:grid;grid-template-columns:1.18fr 1fr;gap:70px;min-height:380px}.model-panel .eyebrow{color:var(--orange)}.model-panel h3{font-size:36px;line-height:1.2;margin:16px 0 20px}.model-panel>div>p:not(.eyebrow){font-size:15px;color:#bfbfbf;line-height:1.7}.model-panel .text-link{font-size:12px;color:white;margin-top:22px}.model-sheet{border:1px solid #d0d0d0;background:#fbfbfb;color:var(--ink);padding:27px 30px;transform:rotate(1deg);align-self:center;box-shadow:9px 9px 0 #ffffff12}.sheet-header{display:flex;justify-content:space-between;align-items:center;margin-bottom:20px}.sheet-header span{font-size:9px;font-weight:750;letter-spacing:.1em;color:#616161}.model-panel .model-sheet #model-question{font:650 22px/1.4 Manrope;letter-spacing:-.025em;color:var(--ink)}.sheet-line{height:1px;background:#ddd;margin:20px 0}.tiny-label{font-size:10px;font-weight:750;letter-spacing:.12em;line-height:1.6}.model-panel .model-sheet .sheet-evidence{font-size:12px;line-height:1.7;color:#555;margin-top:7px}.article-layout{display:grid;grid-template-columns:220px minmax(0,870px);gap:80px;align-items:start}.sidebar{position:sticky;top:35px}.toc{display:flex;flex-direction:column;gap:0}.toc .eyebrow{margin-bottom:17px}.toc a{text-decoration:none;color:#636363;font-size:12px;line-height:1.5;padding:10px 0;border-bottom:1px solid #ededed}.toc a:hover,.toc a.active{color:#a54800}.side-tool{border-left:2px solid var(--orange);padding-left:16px;margin-top:32px}.side-tool .eyebrow{font-size:8px}.side-tool p{font-size:19px;line-height:1.4;letter-spacing:-.025em;margin:10px 0}.side-tool a{font-size:11px;text-decoration:none;font-weight:700}.share-button{font-size:12px;border:0;background:none;padding:0;border-bottom:1px solid #b9b9b9;text-align:left;font-weight:600}.sidebar>.share-button{margin-top:28px}.share-status{font-size:11px;color:#626262;line-height:1.5;margin-top:8px}.article-section{margin-bottom:82px;scroll-margin-top:40px}.article-section>.eyebrow{margin-bottom:15px}.article-section h2{margin-bottom:26px;font-size:44px}.article-section>p{font-size:17px;color:#454545;line-height:1.82}.article-section>p strong{color:#191919}.article-section>h3{font-size:24px;margin:35px 0 15px;letter-spacing:-.03em}.article-section p a:not(.source){color:#9c4600;font-weight:600;text-decoration-thickness:1px}.article-section p .source{font-size:12px;color:#9c4600;vertical-align:super;text-decoration:none;margin-left:2px}.article-section .caption{font-size:12px;line-height:1.6;color:#767676;margin:13px 0 26px}.rail-diagram{display:flex;align-items:center;justify-content:space-between;background:#161616;color:#fff;border-top:3px solid var(--orange);padding:28px 22px;gap:8px;margin-top:30px}.rail-diagram>div{flex:1}.rail-diagram span{font-size:8px;letter-spacing:.12em;color:#ffad46;display:block;margin-bottom:9px}.rail-diagram strong{font:600 17px/1.4 Manrope;letter-spacing:-.02em}.rail-diagram>b{font-weight:400;color:#777;padding:0 6px}.contrast-panel{display:grid;grid-template-columns:.8fr 1.2fr;border:1px solid #dedede;border-top:3px solid var(--orange);margin:29px 0;padding:30px;gap:28px;background:#fafafa}.contrast-panel>div+div{border-left:1px solid #ddd;padding-left:28px}.contrast-panel h3{font-size:32px;margin-top:14px}.contrast-panel p{font-size:12px;color:#777;margin-top:13px}.contrast-panel ul{font-size:14px;line-height:1.7;margin:14px 0 0;padding-left:17px}.contrast-panel li+li{margin-top:7px}.pullquote{margin:38px 0;padding:30px 32px 30px 48px;position:relative;border-left:3px solid var(--orange);background:#f7f7f7}.pullquote>span{color:#d26600;font:70px/1 Georgia;position:absolute;top:25px;left:17px}.pullquote blockquote{font:600 29px/1.4 Manrope;letter-spacing:-.04em;margin:0 0 20px}.review-grid{display:grid;grid-template-columns:1fr 1fr;gap:0;border-top:1px solid #ddd;border-left:1px solid #ddd;margin:28px 0}.review-grid>div{padding:24px 25px;border-right:1px solid #ddd;border-bottom:1px solid #ddd}.review-grid span{font-size:10px;color:#b55000}.review-grid h3{font-size:24px;margin:12px 0}.review-grid p{font-size:14px;color:#626262;line-height:1.7}.cost-note{background:#f4f4f4;border-left:3px solid var(--orange);padding:25px 28px;margin-top:30px}.cost-note>p{font-size:20px;line-height:1.6;margin-top:12px;letter-spacing:-.02em}.cost-note>p:last-child{font-size:13px;color:#626262;letter-spacing:0;margin-top:15px}.table-wrap{margin:30px 0;overflow:auto;border:1px solid #ddd;border-radius:4px}table{border-collapse:collapse;width:100%;font-size:14px;line-height:1.7}caption{text-align:left;padding:18px 20px;background:#f0f0f0;color:#353535;font-size:13px;font-weight:650}thead th{background:#181818;color:#fff;font-size:11px;text-transform:uppercase;letter-spacing:.07em;text-align:left;padding:16px 20px}tbody th{color:#181818;background:#f5f5f5;width:29%;font-weight:650;text-align:left}tbody td{color:#474747;background:#fff}tbody td,tbody th{padding:18px 20px;border-bottom:1px solid #dedede;vertical-align:top}tbody tr:last-child>*{border:0}.article-cta{background:#181818;color:#fff;border-top:3px solid var(--orange);padding:35px;margin-top:36px}.article-cta .eyebrow{color:var(--orange)}.article-cta h3{font-size:32px;margin:15px 0}.article-cta p{font-size:15px;color:#c5c5c5;line-height:1.7;max-width:590px}.article-cta .button{font-size:14px;margin-top:25px}.operations-list{padding:0;margin:30px 0;list-style:none;counter-reset:ops}.operations-list li{counter-increment:ops;padding:27px 0 27px 64px;border-top:1px solid #ddd;position:relative}.operations-list li:last-child{border-bottom:1px solid #ddd}.operations-list li:before{content:'0' counter(ops);position:absolute;left:0;top:28px;color:#b95400;font-size:15px;font-weight:600}.operations-list li>span{font-size:9px;letter-spacing:.13em;color:#777}.operations-list h3{font-size:25px;margin:9px 0 14px}.operations-list p{font-size:15px;color:#626262;line-height:1.8}.note{background:#f4f4f4;padding:24px 28px;margin-top:28px;border-left:2px solid var(--orange);font-size:15px;line-height:1.8}.note p{margin-top:8px;color:#555}.note p:first-child{margin-top:0}details{border-bottom:1px solid #ddd;padding:0}details:first-of-type{border-top:1px solid #ddd}summary{list-style:none;cursor:pointer;font-size:17px;line-height:1.5;font-weight:650;padding:23px 40px 23px 0;position:relative}summary::-webkit-details-marker{display:none}summary:after{content:'+';position:absolute;right:5px;top:22px;font-size:25px;font-weight:400;color:#a94e00}details[open] summary:after{content:'−'}details p{font-size:15px;line-height:1.8;color:#555;padding:0 26px 24px 0}.sources h2{font-size:35px}.sources>p{font-size:14px}.sources ol{padding-left:22px;font-size:13px;line-height:1.7}.sources li{padding:8px 0;color:#666}.sources li a{color:#525252;text-decoration-color:#ccc}.endcap{background:#141414;color:#fff;padding:65px 65px;display:grid;grid-template-columns:1.2fr 1fr;gap:80px;margin-top:10px;margin-bottom:80px;border-top:3px solid var(--orange)}.endcap .eyebrow{color:var(--orange)}.endcap h2{font-size:49px;margin:20px 0 25px}.endcap h2 span{color:var(--orange)}.endcap p:not(.eyebrow){font-size:16px;line-height:1.7;color:#bdbdbd}.endcap .button{font-size:14px;margin-top:25px}.endcap small{display:block;font-size:10px;color:#aaa;margin-top:14px}.endcap-links{align-self:center}.endcap-links>.tiny-label{color:#aaa;display:block;margin-bottom:20px}.endcap-links a{display:flex;justify-content:space-between;align-items:center;gap:20px;font-size:14px;text-decoration:none;padding:20px 0;border-bottom:1px solid #3b3b3b}.endcap-links a span{color:var(--orange)}.endcap-links a:last-child{display:block;margin-top:10px}.endcap-links a:last-child span{display:block;font-size:25px;margin-top:5px}footer{background:#090909;color:#c1c1c1;padding:40px 0}.footer-top{display:flex;align-items:center;justify-content:space-between;gap:30px;padding-bottom:30px;border-bottom:1px solid #2c2c2c}.footer-top img{width:150px;height:auto}.footer-top>span{font-size:13px}.footer-top>a:last-child{font-size:13px;text-decoration:none}.footer-bottom{display:flex;justify-content:space-between;gap:30px;padding-top:22px;font-size:10px;color:#8d8d8d}.footer-bottom p+p{margin:0}dialog{border:1px solid #ddd;border-top:4px solid var(--orange);padding:45px;width:min(600px,calc(100% - 32px));max-height:90vh;overflow:auto;color:#161616;background:#fff}dialog::backdrop{background:#000a;backdrop-filter:blur(4px)}dialog h2{font-size:39px;margin:15px 0 25px}dialog>p:not(.eyebrow){font-size:15px}dialog .note{font-size:13px}dialog .button{margin-top:23px}.dialog-close{position:absolute;top:10px;right:15px;border:0;background:none;font-size:30px;color:#555}.peptide-tools{margin-bottom:82px}
@media(min-width:1700px){.hero-art{object-position:center 60%}.hero{min-height:850px}.hero-inner{padding-top:75px}.hero h1{font-size:106px}.hero-caption{right:max(48px,calc((100% - 1320px)/2));bottom:65px}}
@media(max-width:1100px){.shell{width:calc(100% - 64px)}.site-header{padding:0 32px}.site-header nav{gap:20px}.site-header nav>a:not(.button){display:none}.hero{min-height:760px}.hero h1{font-size:78px}.hero-art{object-position:57% center}.hero-shade{background:linear-gradient(90deg,#070707 0%,#070707e0 28%,#07070720 75%),linear-gradient(0deg,#070707d9,transparent 45%)}.hero-deck{font-size:22px}.hero-copy{max-width:390px}.hero-caption{width:205px;right:4%;bottom:47px}.hero-caption p{font-size:16px}.hero-actions{gap:16px}.hero-actions .quiet-link{font-size:11px}.guide-strip{padding:24px 32px;gap:20px}.guide-strip strong{font-size:13px}.guide-strip small{font-size:11px}.opening{gap:8%;padding-top:85px;padding-bottom:80px}.opening .lead{font-size:21px}.model-panel{gap:35px;padding:36px}.model-tabs button{font-size:12px;padding:18px}.model-panel h3{font-size:31px}.model-panel .model-sheet #model-question{font-size:20px}.article-layout{grid-template-columns:175px minmax(0,1fr);gap:40px}.article-section h2{font-size:39px}.rail-diagram{padding:23px 17px}.rail-diagram strong{font-size:14px}.rail-diagram>b{padding:0}.rail-diagram span{font-size:7px}.contrast-panel{padding:24px;gap:20px}.contrast-panel>div+div{padding-left:20px}.contrast-panel h3{font-size:28px}.endcap{padding:45px;gap:45px}.endcap h2{font-size:42px}.endcap-links a{font-size:12px}.footer-top>span{display:none}}
@media(max-width:800px){.shell{width:calc(100% - 40px)}.site-header{height:75px;padding:0 20px}.brand{gap:13px}.brand img{width:129px}.brand-domain{font-size:18px;padding-left:13px}.button.small{font-size:11px;padding:11px 13px;gap:10px}.button.small span{font-size:18px}.hero{min-height:830px}.hero-inner{padding-top:44px;padding-bottom:30px}.hero h1{font-size:72px}.hero-art{height:100%;object-position:59% center;opacity:.65}.hero-shade{background:linear-gradient(90deg,#070707f5,#070707b0 48%,#07070730),linear-gradient(0deg,#070707,transparent 65%)}.hero-caption{display:none}.hero-copy{max-width:400px}.hero-meta{margin-top:38px}.guide-strip{padding:23px 20px;gap:18px}.guide-strip>div{gap:9px}.guide-strip small{display:none}.guide-strip strong{font-size:12px}.guide-strip>div>span{font-size:9px}.opening{grid-template-columns:1fr;gap:33px;padding-top:70px;padding-bottom:70px}.opening h2{font-size:48px}.opening h2 br:last-of-type{display:none}.side-caption{max-width:360px;margin-top:20px}.opening .lead{font-size:23px}.section-top{display:block}.section-top h2{font-size:39px}.section-top>p{width:auto;max-width:530px;margin-top:20px}.model-tabs button{font-size:12px;padding:16px 13px}.model-panel{grid-template-columns:1fr 1fr;gap:24px;padding:30px 24px}.model-panel h3{font-size:29px}.model-panel>div>p:not(.eyebrow){font-size:13px}.model-panel .text-link{font-size:11px}.model-sheet{padding:23px 20px}.model-panel .model-sheet #model-question{font-size:18px}.sheet-header span{font-size:7px}.article-layout{display:block}.sidebar{display:none}.article-section h2{font-size:42px}.article-section>p{font-size:17px}.model-section{padding-bottom:70px}.endcap{grid-template-columns:1fr;gap:40px;padding:40px 30px;margin-bottom:45px}.endcap-links a{font-size:14px}.endcap-links a:last-child{display:flex}.endcap-links a:last-child span{font-size:17px}.footer-bottom{display:block}.footer-bottom p+p{margin-top:8px}}
@media(max-width:520px){.site-header .button.small{padding:10px;font-size:10px;gap:6px;max-width:106px}.brand img{width:107px}.brand-domain{font-size:15px;letter-spacing:-.045em}.brand{gap:10px}.brand-domain{padding-left:10px}.hero{min-height:920px}.hero-art{height:500px;top:0;object-fit:cover;object-position:78% center;opacity:.78}.hero-shade{background:linear-gradient(0deg,#080808 0%,#080808 38%,#0808084d 72%,#08080820),linear-gradient(90deg,#080808c9,#08080800)}.hero-inner{padding-top:32px;position:relative}.edition{font-size:8px;gap:8px;letter-spacing:.1em}.edition-line{width:18px}.hero h1{font-size:62px;line-height:1.03;margin-top:215px}.hero-deck{font-size:21px;margin-top:23px}.hero-copy{font-size:14px;line-height:1.7;max-width:340px}.hero-actions{margin-top:25px;align-items:flex-start;gap:16px;flex-direction:column}.hero-actions .button{padding:14px 18px;font-size:13px}.hero-actions .quiet-link{font-size:12px}.hero-meta{font-size:9px;gap:10px;margin-top:29px}.hero-meta span+span{padding-left:10px}.guide-strip{grid-template-columns:1fr;padding:25px 20px;gap:18px}.guide-strip>div{align-items:center;gap:16px}.guide-strip strong{font-size:13px}.guide-strip small{display:block;font-size:11px}.guide-strip>div>span{font-size:10px;padding:0}.opening{padding-top:56px;padding-bottom:56px}.opening h2{font-size:40px}.opening .lead{font-size:21px}.opening-copy>p:not(.lead){font-size:16px}.section-top h2{font-size:34px}.section-top>p{font-size:14px}.model-tabs{grid-template-columns:1fr}.model-tabs button{display:flex;align-items:center;gap:15px;padding:16px 17px;border:0;border-bottom:1px solid #ddd;font-size:13px}.model-tabs button span{margin:0;font-size:10px}.model-panel{grid-template-columns:1fr;padding:27px 22px;gap:28px}.model-panel h3{font-size:30px}.model-panel>div>p:not(.eyebrow){font-size:14px}.model-sheet{transform:none;padding:23px}.model-panel .model-sheet #model-question{font-size:21px}.sheet-header span{font-size:9px}.model-section{padding-bottom:60px}.article-section{margin-bottom:58px}.article-section h2{font-size:34px;line-height:1.18}.article-section>p{font-size:16px;line-height:1.85}.article-section>.eyebrow{font-size:9px}.rail-diagram{display:grid;grid-template-columns:1fr 1fr;gap:25px;padding:24px}.rail-diagram>b{display:none}.rail-diagram strong{font-size:18px}.rail-diagram span{font-size:8px}.contrast-panel{grid-template-columns:1fr;padding:25px;gap:23px}.contrast-panel>div+div{border-left:0;border-top:1px solid #ddd;padding-left:0;padding-top:20px}.contrast-panel h3{font-size:32px}.contrast-panel ul{font-size:14px}.pullquote{padding:28px 22px 28px 36px}.pullquote>span{left:10px}.pullquote blockquote{font-size:24px}.review-grid>div{padding:19px 16px}.review-grid h3{font-size:21px}.review-grid p{font-size:12px}.cost-note{padding:22px}.cost-note>p{font-size:19px}.table-wrap table{font-size:12px}.table-wrap caption{font-size:12px;padding:14px}.table-wrap th,.table-wrap td{padding:14px 12px}.table-wrap thead th{font-size:9px}.article-cta{padding:26px 22px}.article-cta h3{font-size:28px}.article-cta .button{font-size:12px;padding:16px;gap:15px}.operations-list li{padding-left:43px}.operations-list h3{font-size:23px}.operations-list p{font-size:14px}summary{font-size:16px;padding-top:20px;padding-bottom:20px}details p{font-size:14px}.sources h2{font-size:29px}.sources>p{font-size:13px}.sources ol{font-size:12px;overflow-wrap:anywhere}.endcap{padding:32px 24px;gap:30px}.endcap h2{font-size:37px}.endcap p:not(.eyebrow){font-size:14px}.endcap .button{font-size:12px;padding:16px 18px;gap:20px}.endcap-links a{font-size:12px}.endcap-links a:last-child{display:block}.endcap-links a:last-child span{font-size:24px}.footer-top{flex-direction:column;align-items:flex-start;gap:23px;padding-bottom:25px}.footer-top img{width:145px}.footer-bottom{font-size:9px}dialog{padding:37px 25px}dialog h2{font-size:33px}.peptide-tools{margin-bottom:58px}}
@media(prefers-reduced-motion:reduce){html{scroll-behavior:auto}*,*:before,*:after{transition:none!important;animation:none!important}.button:hover{transform:none}}
.volume-section{padding-bottom:100px}.volume-section .section-top>p{width:320px}.volume-grid{display:grid;grid-template-columns:1fr 1fr;border:1px solid #ddd}.volume-card{padding:36px 38px;display:flex;flex-direction:column}.volume-priority{background:#111;color:#fff;border-top:4px solid var(--orange)}.volume-search{background:#f6f6f6;color:#111;border-top:4px solid #c4c4c4}.volume-tag{font-size:9px;letter-spacing:.14em;font-weight:750;line-height:1.5}.volume-priority .volume-tag{color:var(--orange)}.volume-search .volume-tag{color:#666}.volume-card h3{font-size:52px;line-height:1.15;margin:28px 0 4px}.volume-card h3 span{color:var(--orange)}.volume-search h3{font-size:41px;margin-top:34px}.volume-card .volume-unit{font-size:13px;color:#bfbfbf;margin:0}.volume-search .volume-unit{color:#626262}.volume-promise{padding:24px 0;border-top:1px solid #ffffff2e;border-bottom:1px solid #ffffff2e;margin:27px 0 24px}.volume-search .volume-promise{border-color:#d7d7d7}.volume-promise>strong{display:block;font:700 38px/1.2 Manrope;letter-spacing:-.04em;color:var(--orange)}.volume-search .volume-promise>strong{color:#111;font-size:33px}.volume-promise>strong>span{font-size:25px;font-weight:500;letter-spacing:-.03em}.volume-promise>p{font-size:12px;letter-spacing:.01em;margin-top:10px;color:#cfcfcf}.volume-search .volume-promise>p{color:#5c5c5c}.volume-card>p:not(.volume-unit){font-size:15px;line-height:1.8;color:#c4c4c4;flex:1;margin:0 0 27px}.volume-card>p strong{color:#fff;font-weight:650}.volume-search>p:not(.volume-unit){color:#4f4f4f}.volume-card>.button{font-size:14px;align-self:flex-start;padding:16px 22px;gap:25px}.volume-secondary{background:#151515;color:#fff}.volume-secondary:hover{background:#343434}.volume-details{display:grid;grid-template-columns:1fr 1fr;gap:35px;margin-top:24px}.volume-details p{margin:0;font-size:12px;line-height:1.8;color:#626262}.volume-details strong{color:#333}.regulatory-callout{background:#141414;color:#fff;padding:30px 33px;border-top:3px solid var(--orange);margin-top:30px}.regulatory-callout .tiny-label{color:var(--orange);font-size:9px}.regulatory-callout h3{font-size:32px;line-height:1.25;margin:15px 0 20px}.regulatory-callout p{font-size:15px;line-height:1.8;color:#d0d0d0}.regulatory-callout .source{color:var(--orange)!important}.regulatory-table{margin-top:22px}.regulatory-table caption{font-size:12px;line-height:1.7}.regulatory-table tbody th{width:30%;white-space:normal}.regulatory-table td{font-size:13px}.approval-examples{display:grid;grid-template-columns:1fr 1fr;border:1px solid #ddd;margin:27px 0}.approval-examples>div{padding:27px 26px;display:flex;flex-direction:column}.approval-examples>div+div{border-left:1px solid #ddd}.approval-kind{font-size:8px;font-weight:750;letter-spacing:.1em;color:#9a4700}.approval-examples time{display:block;font-size:11px;color:#666;margin-top:10px}.approval-examples h4{font:750 30px/1.2 Manrope;letter-spacing:-.045em;margin:20px 0}.approval-examples h4>span{display:block;font:400 14px/1.4 var(--font);letter-spacing:0;color:#777;margin-top:5px}.approval-examples p{font-size:13px;line-height:1.8;color:#535353;flex:1}.approval-examples a{font-size:11px;line-height:1.7;margin-top:20px;color:#8e4300;font-weight:600;text-decoration:none}.approval-examples a span{font-weight:400}.guidance-update{border-left:3px solid var(--orange);background:#f5f5f5;padding:28px 30px;margin:28px 0 34px}.guidance-update .tiny-label{font-size:9px;color:#666}.guidance-update h3{font-size:26px;margin:12px 0 18px}.guidance-update p{font-size:14px;line-height:1.8;color:#535353}.regulatory-dateline{border-top:1px solid #ddd;border-bottom:1px solid #ddd;padding:19px 0;margin-top:26px}.regulatory-dateline>strong{font-size:13px}.regulatory-dateline p{font-size:12px;line-height:1.8;color:#777;margin-top:7px}
@media(max-width:1100px){.volume-card{padding:30px}.volume-card h3{font-size:43px}.volume-search h3{font-size:34px;margin-top:35px}.volume-card>.button{font-size:12px;padding:16px 18px;gap:15px}.volume-promise>strong{font-size:34px}.volume-search .volume-promise>strong{font-size:29px}.volume-promise>strong>span{font-size:22px}.volume-card>p:not(.volume-unit){font-size:14px}.volume-section .section-top>p{width:290px}}
@media(max-width:800px){.volume-section{padding-bottom:70px}.volume-section .section-top>p{width:auto}.volume-card{padding:28px 24px}.volume-card h3{font-size:36px}.volume-search h3{font-size:28px;margin-top:34px}.volume-tag{font-size:8px}.volume-card .volume-unit{font-size:11px}.volume-promise>strong{font-size:30px}.volume-search .volume-promise>strong{font-size:26px}.volume-promise>strong>span{font-size:20px}.volume-card>p:not(.volume-unit){font-size:13px}.volume-card>.button{align-self:stretch;font-size:11px;gap:12px;padding:15px}.volume-details{gap:25px}.volume-details p{font-size:11px}}
@media(max-width:600px){.volume-grid{grid-template-columns:1fr}.volume-card{padding:29px 25px}.volume-card h3{font-size:46px}.volume-search h3{font-size:35px;margin-top:27px}.volume-tag{font-size:9px}.volume-card .volume-unit{font-size:12px}.volume-promise{padding:22px 0;margin:25px 0 21px}.volume-promise>strong{font-size:38px}.volume-search .volume-promise>strong{font-size:32px}.volume-promise>strong>span{font-size:24px}.volume-card>p:not(.volume-unit){font-size:14px}.volume-card>.button{font-size:12px;gap:18px}.volume-details{grid-template-columns:1fr;gap:17px}.volume-details p{font-size:12px}.regulatory-callout{padding:25px}.regulatory-callout h3{font-size:28px}.regulatory-callout p{font-size:14px}.regulatory-table th,.regulatory-table td{padding:14px 12px}.regulatory-table td{font-size:12px}.regulatory-table tbody th{font-size:12px}.approval-examples{grid-template-columns:1fr}.approval-examples>div{padding:25px}.approval-examples>div+div{border-left:0;border-top:1px solid #ddd}.approval-kind{font-size:9px}.approval-examples h4{font-size:32px;margin:17px 0}.approval-examples p{font-size:14px}.approval-examples a{font-size:12px}.guidance-update{padding:24px}.guidance-update h3{font-size:26px}.guidance-update p{font-size:14px}}
@media print{.site-header,.sidebar,.hero-actions,.hero-caption,.read-progress,.model-tabs,.share-button,dialog,.button,footer{display:none!important}.hero{min-height:0;background:#fff;color:#111}.hero-art,.hero-shade{display:none}.hero-inner{padding:30px 0}.hero h1{font-size:45px}.hero h1 br{display:none}.hero-copy,.hero-meta{color:#555}.shell{width:100%}.opening{padding:30px 0}.article-layout{display:block}.article-section{break-inside:avoid-page}.model-panel{background:#f4f4f4;color:#111}.model-panel>div>p:not(.eyebrow){color:#444}.endcap{display:block;background:#fff;color:#111}.endcap p:not(.eyebrow){color:#444}.volume-section{padding-bottom:40px}.volume-grid{display:block}.volume-card{break-inside:avoid}.regulatory-callout{background:#fff;color:#111}.regulatory-callout p{color:#444}.approval-examples{display:block}}
.volume-details>p:first-child{grid-column:1/-1}